May 2010
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Making Practical Sense of Cytochrome P450
Guidelines for the likely 20 to 30% of pain patients who have a genetic defect
involving one of three major CYP450 enzymes and so cannot effectively metabolize certain
opioids that must be converted to a metabolite to be effective.
by Forest Tennant, MD, DrPH
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Non-Pharmacologic Treatment of Shingles
Shingles pain and lesions resolved in 48 hours after treatment with frequency-specific
microcurrent.
by Carolyn McMakin, MA, DC
Treatment of Painful Cutaneous Wounds
Comprehensive management and pain control are critical for patients with chronic wounds
in order to improve outcomes and speed healing.
by Michael Maier, DPM
Guest Editorial: Treating Myofacial and Other Idiopathic Head and Neck Pain
Neuromuscular dentistry looks at the system as a whole, including teeth and
bones, together with a comprehensive evaluation of the musculature involved.
by Mark Duncan, DDS, FAGD, DICOI, LVIF
In Memoriam: David G. Simons, MD
by Carolyn McMakin, MA, DC
Publisher's Message: A Meaningful Exchange
by Marvin Rosenfeld
Ethics and Health Policy: Pain, Neurotechnology and the Treatment-Enhancement Debate
Protocols for the use of medical interventions should be frequently assessed, revised
and followed by reflective evaluation and prudent governance to establish guidelines and
policies.
by James Giordano, PhD, Mphil; Justin Rossi, BSc; and Adriana Gini, MD
Clinical Report: Functional Capacity Evaluation (FCE)
While not yet precise enough as a predictive tool, FCE can be combined with other
sources of information such as medical, rehabilitative and diagnostic data to help resolve
issues of compensability, disability and employability.
by Tiziano Marovino, DPT, DAAPM
Prolotherapy: The New Age of Prolotherapy
In addition to traditional prolotherapy, platelet-rich plasma and stem cells are also
available to enhance healing of musculoskeletal injuries and mitigation of pain.
by Donna Alderman, DO
Laser Therapy: Enhancement of Nerve Regeneration by Therapeutic Laser
Therapeutic laser shows promise as an accelerator of healing and neural regeneration in
the central nervous system.
by William J. Kneebone, RN, DC
Headache: Chaos (Nonlinear Dynamics) and Migraine
By affecting chaotic (nonlinear) controls, whereby a tiny change in initial
conditions may lead to a profound difference later in the process, new therapies may
be employed that use less drug in the migraine cascade than is currently required.
by Lawrence Robbins, MD and Cameron Leith, PhD
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